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Product name : CUDC 101
Item : cc381
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1012054-59-9
Molecular Weight : 434.49
Formula : C₂₄H₂₆N₄O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.Because of its integrated histone deacetylase inhibition, CUDC101 synergistically blocked key regulators of EGFR/HER2 signaling pathways, also attenuating multiple compensatory pathways, such as AKT, HER3, and MET, which enable cancer cells to escape the effects of conventional EGFR/HER2 inhibitors. CUDC 101 displayed potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs. [1][2]
 
Reference:
[1] Cancer Res. 2010, 70, 3647-3656.
[2] J Med. Chem. 2010, 53, 2000-2009.
 
 
Chemical Information
Molecular Weight (WM):
435.48
Formula:
C24H26N4O4
CAS No:
1012054-59-9
Purity:
≥ 98%
Synonyms:
CUDC 101
 
DMSO ≥ 43 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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