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Product name : BMS 536924
Item : cc534
Price : 10mg, $275; 50mg, $715; 100mg, $1295; 200mg, $2295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
BMS-535924 is a potent inhibitor of the IGF-1 receptor in vitro  (IC50 = 100 nM).BMS536924 has been shown to inhibit the catalytic activityof IGF-1R and its down stream signaling components such as Aktand MAPK in cells; it also inhibits proliferation in a widevariety of human cancer cell lines including, colon, breast,lung, pancreas, prostate, sarcoma and multiple myeloma. In vivo,BMS-536924 inhibits tumor growth in an IGF-1R-dependent tumormodel (IGF-1R Sal) as well as in a broad range of human tumorxenografts. [1][2]
 
Reference:
[1] J Med. Chem. 2008, 51, 5897-5900.
[2] Br. J Pharmacol. 2007, 64, 292-303.
 
 
Chemical Information
Molecular Weight (WM):
479.96
Formula:
C25H26ClN5O5
CAS No:
468740-43-4
Purity:
≥ 98%
Synonyms:
BMS 536924
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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