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Products > Receptor Tyrosine Kinase > IGF-1R > NVP-AEW541 (AEW 541)
Product name : NVP-AEW541 (AEW 541)
Item : cc535
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 475489-16-8
Molecular Weight : 439.55
Formula : C₂₇H₂₉N₅O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
NVP-AEW541 (AEW541) is a selective IGF-1R kinase inhibitor. In vitro, AEW-541 inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 µM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 µM, respectively). Insulin-like growth factor 1 receptor (IGF-1R) is a receptor tyrosine kinase whose activation leads to angiogenesis as well as cell proliferation, survival, transformation, and metastasis. IGF-1R signaling has been implicated in the development and progression of cancer.  [1][2]
 
Reference:
[1] Clin. Cancer Res. 2006, 12, 6772-6780.
[2] Cancer Cell 2004, 5, 231-239.
 
 
Chemical Information
Molecular Weight (WM):
439.55
Formula:
C27H29N5O
CAS No:
475489-16-8, 475488-34-7
Purity:
≥ 98%
Synonyms:
AEW 541, AEW-541
 
DMSO ≥ 88 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 88 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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