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Product name : Crenolanib (CP 868596)
Item : cc84
Price : 10mg, $265; 50mg, $795; 100mg, $1295; 200mg, $2195
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Crenolanib (CP-868596) is a highly selective and potent PDGFR-α inhibitor with IC50 of 0.9 and 1.8 nM against PDGFRα and PDGFRβ, respectively. In addition,Crenolanib (CP868596) inhibits the activity of PDGFRα D842V kinase with an IC50 of 1 nM. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation. PDGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature.  [1][2]
 
Reference:
[1] Br. J Cancer 2010, 103, 1554-1561.
[2] J Clin. Oncol. 2009, 27, 5262-5269.
 
 
Chemical Information
Molecular Weight (WM):
443.54
Formula:
C26H29N5O2
CAS No:
670220-88-9, 670220-93-6 (benzenesulfonate)
Purity:
≥ 98%
Synonyms:
CP 868596
 
DMSO ≥ 89 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 7 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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