Apoptosis
Btk
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Product name : Bosutinib (SKI 606)
Item : cc357
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 380843-75-4
Molecular Weight : 530.45
Formula : C₂₆H₂₉Cl₂N₅O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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| Details: | |||||||||||||||||||||||||
Bosutinib (SKI-606) is a novel dual Sarcoma/Abelson (Src/Abl) tyrosine kinase inhibitor with IC50 values of 1.2 nM and 1 nM, respectively. Bosutinib (SKI606) inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis. Because of the dual mechanism of action, this agent may have activity in resistant CML disease, other myeloid malignancies and solid tumors. Abl kinase is upregulated in the presence of the abnormal Bcr-abl fusion protein which is commonly associated with chronic myeloid leukemia (CML). Overexpression of specific Src kinases is also associated with the imatinib-resistant CML phenotype. [1][2]
Reference:
[1] Mol. Cancer Ther. 2008, 7, 1185-1194.
[2] J Med. Chem. 2006, 49, 7868-7876.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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