Product name : Danusertib (PHA 739358)
Item : cc361
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 827318-97-8
Molecular Weight : 474.55
Formula : C₂₆H₃₀N₆O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Danusertib (PHA-739358) is a pyrrolo-pyrazole and small molecule aurora kinases and Bcr-Abl kinase inhibitor for aurora A, B, and C with IC50 of 13 nM, 79 nM, and 61 nM, respectively. PHA739358 inhibits all Aurora kinase family members and shows a dominant Aurora B kinase inhibition-related cellular phenotype and mechanism of action in cells in vitro and in vivo. PHA 739358 has significant antitumor activity in different xenografts and spontaneous and transgenic animal tumor models and shows a favorable pharmacokinetic and safety profile. [1][2]
Reference: [1] Cancer Res. 2007, 67, 7987-7990.
[2] Blood 2008, 111, 4355-4364.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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