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Product name : Danusertib (PHA 739358)
Item : cc361
Price : 10mg, $255; 50mg, $825; 100mg, $1295; 200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Danusertib (PHA-739358) is a pyrrolo-pyrazole and small molecule aurora kinases and Bcr-Abl kinase inhibitor for aurora A, B, and C with IC50 of 13 nM, 79 nM, and 61 nM, respectively.  PHA739358 inhibits all Aurora kinase family members and shows a dominant Aurora B kinase inhibition-related cellular phenotype and mechanism of action in cells in vitro and in vivo. PHA 739358 has significant antitumor activity in different xenografts and spontaneous and transgenic animal tumor models and shows a favorable pharmacokinetic and safety profile.   [1][2]

Reference:
[1] Cancer Res. 2007, 67, 7987-7990.
[2] Blood 2008, 111, 4355-4364.
 

Chemical Information
Molecular Weight (WM):
474.55
Formula:
C26H30N6O3
CAS No:
827318-97-8
Purity:
≥ 98%
Synonyms:
PHA 739358
 
DMSO ≥ 95 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 34 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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