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Product name : Saracatinib (AZD 0530)
Item : cc81
Price : 10mg, $60; 50mg, $195; 100mg, $345; 200mg; $595
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively. Saracatinib is a dual-specific inhibitor of Src and Abl, protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. AZD-0530 binds to and inhibits these tyrosine kinases and their effects on cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival. Specifically, saracatinib inhibits Src kinase-mediated osteoclast bone resorption.   [1][2]
 
Reference:
[1] J Med. Chem. 2006, 49, 6465-6488.
[2] J Thorac. Oncol. 2009, 4, 448-454.
 
 
Chemical Information
Molecular Weight (WM):
542.026
Formula:
C27H32ClN5O5
CAS No:
379231-04-6
Purity:
≥ 98%
Synonyms:
AZD 0530
 
DMSO ≥ 108 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 108 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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