Favorite  |  Set Home
Product name : WZ 8040
Item : cc536
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1214265-57-2
Molecular Weight : 481.01
Formula : C₂₄H₂₅ClN₆OS
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
WZ8040 is an irreversiblely EGFR T790M inhibitor (IC50<10nM). WZ-8040 is an irreversiblely inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ 8040 is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wildtype EGFR, than quinazoline-based EGFR inhibitors (HKI-272 and CL-387,785) in vitro.  [1]
 
Reference:
[1] Nature 2009, 462, 1070-1074.
 
 
Chemical Information
Molecular Weight (WM):
481.01
Formula:
C24H25ClN6OS
CAS No:
1214265-57-2
Purity:
≥ 98%
Synonyms:
WZ 8040
 
DMSO ≥ 96 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 3 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
WZ 4002
WZ 4002
Price: 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
AST1306(tosylate)
AST1306(tosylate)
Price: 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
BMS 690514
BMS 690514
Price: 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
Afatinib (BIBW 2992)
Afatinib (BIBW 2992)
Price: 5g, $650;10g, $1050; 20g $1650
Canertinib
Canertinib
Price: 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
Lapatinib (Tykerb)
Lapatinib (Tykerb)
Price: 5g, $650;10g, $1050; 20g $1650
Gefitinib
Gefitinib
Price: 5g, $650;10g, $1050; 20g $1650
CUDC 101
CUDC 101
Price: 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995