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Product name : Lapatinib (Tykerb)
Item : cc250
Price : 5g, $650;10g, $1050; 20g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 231277-92-2
Molecular Weight : 581.06
Formula : C₂₉H₂₆ClFN₄O₄S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 nM and 9.2 nM, respectively.Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.   [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2001, 1, 85-94.
[2] Cancer Res. 2005, 65, 18-25.
 
 
Chemical Information
Molecular Weight (WM):
925.64
Formula:
C29H26ClFN4O4S·2C7H8O3S
CAS No:
388082-77-7, 231277-92-2 (free base), 1187538-35-7 (4-methylbenzenesulfonate)
Purity:
≥ 98%
Synonyms:
GW-572012, GW 572012, GW-2016
 
DMSO ≥ 185 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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