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Product name : CH 5424802
Item : cc247
Price : 10mg, $195; 50mg, $635; 100mg, $995; 200mg, $1755
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
CH5424802 is a potent and selective ALK inhibitor with IC50 of 1.9 nM. Upon administration, ALK inhibitor CH-542480 binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors. The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.   [1][2]
 
Reference:
[1] Cancer Cell 2011, 19, 679-690.
[2] Bioorg. Med. Chem. 2012, 20, 1271-1280.
 
 
Chemical Information
Molecular Weight (WM):
482.62
Formula:
C30H34N4O2
CAS No:
1256580-46-7
Purity:
≥ 98%
Synonyms:
CH 5424802
 
DMSO ≥ 15 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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