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Product name : SB 525334
Item : cc539
Price : 100mg, $500; 200mg, $895
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 356559-20-1
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Details:
SB 525334 is a potent and selective inhibitor of the transforming growth factor-β1 (TGF-β1) receptor (activin receptor-like kinase 5, ALK5) with an IC50 of 14.3 nM.Blockade of TGF-beta signaling with the ALK5/type I TGF-beta R kinase inhibitor, SB525334, was efficacious for uterine leiomyoma; significantly decreasing tumor incidence and multiplicity, and reducing the size of these mesenchymal tumors. However, SB-525334 was also mitogenic and antiapoptotic for epithelial cells in the kidney and exacerbated the growth of epithelial lesions present in the kidneys of these animals.[1][2]
 
Reference:
[1] Clin. Cancer Res. 2007, 13, 3087-3099.
[2] Am. J Pathol. 2009, 174, 380-389.
 
 
Chemical Information
Molecular Weight (WM):
343.42
Formula:
C21H21N5
CAS No:
356559-20-1
Purity:
≥ 98%
Synonyms:
SB-525334
 
DMSO ≥ 69 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 69 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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