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Product name : Dovitinib (TKI-258)
Item : cc257
Price : 100mg, $595; 200mg, $1095;
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 915769-50-5
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Details:
Dovitinib (TKI258, CHIR258) is a novel multitargeted growth factor receptor kinase inhibitor of FLT3, c-KIT, FGFR1/3, VEGFR1/2/3 with IC50 of 1 nM, 2 nM, 8 nM, 9 nM, 10 nM, 13 nM and 8 nM, respectively. Dovitinib strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. The activation of FGFR3 is associated with cell proliferation and survival in certain cancer cell types.  [1][2]
 
Reference:
[1] Blood 2005, 105, 2941-2948.
[2] Clin. Cancer Res. 2005, 11, 3633-3641.
 
 
Chemical Information
Molecular Weight (WM):
392.43
Formula:
C21H21FN6O
CAS No:
405169-16-6
Purity:
≥ 98%
Synonyms:
CHIR 258, CHIR-258, TKI-258, TKI 258
 
DMSO ≥ 115 mg/mL
Solubility (25℃)
Water ≥ 115 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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