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Product name : Crizotinib (PF 2341066)
Item : cc190
Price : 5g, $650;10g, $1050; 20g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 877399-52-5
Molecular Weight : 450.34
Formula : C₂₁H₂₂Cl₂FN₅O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PF-2341066 (Crizotinib) is a potent inhibitor for recombinant human c-Met kinase with Ki of 4 nM. Crizotinib, in an ATP-competitive manner, binds to and inhibits ALK kinase and ALK fusion proteins. In addition, PF2341066 inhibits c-Met kinase, and disrupts the c-Met signaling pathway. Altogether, this agent inhibits tumor cell growth. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.   [1][2]
 
Reference:
[1] Curr. Drug Metab. 2010, 11, 296-306.
[2] N. Engl. J Med. 2010,363, 1727-1733.
 
 
Chemical Information
Molecular Weight (WM):
450.34
Formula:
C21H22Cl2FN5O
CAS No:
877399-52-5
Purity:
≥ 98%
Synonyms:
PF 2341066
 
DMSO ≥ 23 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 8 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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