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Product name : ARQ-197 (Tivantinib)
Item : cc86
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 905854-02-6
Molecular Weight : 369.42
Formula : C₂₃H₁₉N₃O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
ARQ-197 (Tivantinib) is a novel and selective human c-Met receptor tyrosine kinase inhibitor with IC50 of 0.1 μM. ARQ197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing consitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.   [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2010, 9, 1544-1553.
[2] J Clin. Oncol. 2011, 29, 1271-1279.
 

Chemical Information
Molecular Weight (WM):
369.42
Formula:
C23H19N3O2
CAS No:
905854-02-6
Purity:
≥ 98%
Synonyms:
ARG 197
 
DMSO ≥ 74 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 9 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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