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Product name : JNJ-38877605
Item : cc51
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 943540-75-8
Molecular Weight : 377.35
Formula : C₁₉H₁₃F₂N₇
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
JNJ-38877605 is an ATP-competitive inhibitor for the catalytic activity of c-Met with IC50 of 4 nM. JNJ38877605 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.  [1][2]
 
Reference:
[1] Caner Res. 2010, 70, 7580-7590.
[2] J Natl. Cancer Inst. 2011, 103, 645-661.
 
 
Chemical Information
Molecular Weight (WM):
377.35
Formula:
C19H13F2N7
CAS No:
943540-75-8
Purity:
≥ 98%
Synonyms:
JNJ 38877605
 
DMSO ≥ 76 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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