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Product name : SGX 523
Item : cc382
Price : 10mg, $265; 50mg, $645; 100mg, $1195; 200mg, $2095
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
SGX-523 is an exquisitely selective MET receptor tyrosine kinase inhibitor with an IC50 of 4 nM. SGX523 specifically binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.   [1][2]
 
 Reference:
[1] Mol. Cancer Ther. 2009, 8, 3181-3190.
[2] Drug Metab. Dispos. 2010, 38, 1277-1285.
 
 
Chemical Information
Molecular Weight (WM):
359.41
Formula:
C18H13N7S
CAS No:
1022150-57-7
Purity:
≥ 98%
Synonyms:
SGX 523
 
DMSO ≥ 2 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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