Product name : SGX-523
Item : cc382
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1022150-57-7
Molecular Weight : 359.41
Formula : C₁₈H₁₃N₇S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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SGX-523 is an exquisitely selective MET receptor tyrosine kinase inhibitor with an IC50 of 4 nM. SGX523 specifically binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis. [1][2]
Reference:
[1] Mol. Cancer Ther. 2009, 8, 3181-3190.
[2] Drug Metab. Dispos. 2010, 38, 1277-1285.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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