Favorite  |  Set Home
Product name : SGX-523
Item : cc382
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1022150-57-7
Molecular Weight : 359.41
Formula : C₁₈H₁₃N₇S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
SGX-523 is an exquisitely selective MET receptor tyrosine kinase inhibitor with an IC50 of 4 nM. SGX523 specifically binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.   [1][2]
 
 Reference:
[1] Mol. Cancer Ther. 2009, 8, 3181-3190.
[2] Drug Metab. Dispos. 2010, 38, 1277-1285.
 
 
Chemical Information
Molecular Weight (WM):
359.41
Formula:
C18H13N7S
CAS No:
1022150-57-7
Purity:
≥ 98%
Synonyms:
SGX 523
 
DMSO ≥ 2 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

Related Products :
BMS 777607
BMS 777607
Price: 200mg, $750;500mg, $1250; 1g $1850; 2g, $3050
BMS 794833
BMS 794833
Price: 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
NVP-BVU972
NVP-BVU972
Price: 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
PF 04217903
PF 04217903
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
MGCD 265
MGCD 265
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
PHA 665752
PHA 665752
Price: 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
AMG 208
AMG 208
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
ARQ-197 (Tivantinib)
ARQ-197 (Tivantinib)
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590