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Product name : PHA 665752
Item : cc47
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 477575-56-7
Molecular Weight : 641.61
Formula : C₃₂H₃₄Cl₂N₄O₄S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM. c-Met is highly expressed in most tumors from patients with advanced-stage, metastatic NBL. Furthermore, using the NBL cell line SH-EP as a model, PHA665752 was shown to inhibit cMet/HGF/SF signaling in vitro, suggesting c-Met inhibitors may have efficacy for blocking local progression and/or metastatic spread of c-Met-positive NBL in vivo.    [1][2]
 
Reference:
[1] Proc. Natl. Acad. Sci. USA 2006, 103, 2316-2321.
[2] Clin. Cancer Res. 2005, 11, 2312-2319.
 
 
Chemical Information
Molecular Weight (WM):
641.61
Formula:
C32H34Cl2N4O4S
CAS No:
477575-56-7
Purity:
≥ 98%
Synonyms:
PHA 665752
 
DMSO ≥ 128 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 128 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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