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Product name : MGCD 265
Item : cc38
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 875337-44-3
Molecular Weight : 517.6
Formula : C₂₆H₂₀FN₅O₂S₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
MGCD-265 is a potent, multi-target, and ATP-competitive inhibitor of receptor tyrosine kinases, including Met, VEGFR, Ron, and Tie2, with IC50 of 1 nM to 7 nM. MGCD265 binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R or RON). Inhibition of these RTKs and their downstream signaling pathways may result in the inhibition of tumor angiogenesis and tumor cell proliferation in tumors overexpressing these RTKs.  [1][2]
 
Reference:
[1] Cancer Res. 2003, 63, 5462-5469.
[2] Oncogene 2004, 23, 5387-5393.
 
 
Chemical Information
Molecular Weight (WM):
517.60
Formula:
C26H20FN5O2S2
CAS No:
875337-44-3
Purity:
≥ 98%
Synonyms:
MGCD 265
 
DMSO ≥ 104 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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