Apoptosis
DPP4
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Product name : UK 383367
Item : cc548
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 348622-88-8
Molecular Weight : 324.38
Formula : C₁₅H₂₄N₄O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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UK 383367 is a novel, potent procollagen C-proteinase (PCP) inhibitor with an IC50 of 44 nM. In the fibroplasia model, UK-383367 inhibited deposition of insoluble collagen by 76 ± 2% at 10 μM. UK 383367 was very effective at penetrating human skin in vitro with a transepidermal delivery flux of 1.5 μg/cm2/h, which compares favorably with values for agents that are known to penetrate skin well in vivo.UK383367 is used for the treatment of post-surgical dermal scarring. UK 383367 is selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 >10 μM for them). [1][2]
Reference: [1] J Med. Chem. 2007, 50, 3442-3456.
[2] Bioorg. Med. Chem. Lett. 2008, 18, 6562-6567.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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