Favorite  |  Set Home
Products > Protease > Protease > UK 383367
Product name : UK 383367
Item : cc548
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 348622-88-8
Molecular Weight : 324.38
Formula : C₁₅H₂₄N₄O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
UK 383367 is a novel, potent procollagen C-proteinase (PCP) inhibitor with an IC50 of 44 nM. In the fibroplasia model, UK-383367 inhibited deposition of insoluble collagen by 76 ± 2% at 10 μM. UK 383367 was very effective at penetrating human skin in vitro with a transepidermal delivery flux of 1.5 μg/cm2/h, which compares favorably with values for agents that are known to penetrate skin well in vivo.UK383367 is used for the treatment of post-surgical dermal scarring. UK 383367 is selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 >10 μM for them).  [1][2]
 
Reference:
[1] J Med. Chem. 2007, 50, 3442-3456.
[2] Bioorg. Med. Chem. Lett. 2008, 18, 6562-6567.
 
 
Chemical Information
Molecular Weight (WM):
324.38
Formula:
C15H24N4O4
CAS No:
348622-88-8
Purity:
≥ 98%
Synonyms:
UK 383367
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
PF 429242
PF 429242
Price: 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
Camostat
Camostat
Price: 5g, $650;10g, $1050; 20g $1650
BCX 1470
BCX 1470
Price: 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995