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Product name : UK 383367
Item : cc548
Price : 10mg, $75, 50mg, $245; 100mg, $445; 200mg, $795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
UK 383367 is a novel, potent procollagen C-proteinase (PCP) inhibitor with an IC50 of 44 nM. In the fibroplasia model, UK-383367 inhibited deposition of insoluble collagen by 76 ± 2% at 10 μM. UK 383367 was very effective at penetrating human skin in vitro with a transepidermal delivery flux of 1.5 μg/cm2/h, which compares favorably with values for agents that are known to penetrate skin well in vivo.UK383367 is used for the treatment of post-surgical dermal scarring. UK 383367 is selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 >10 μM for them).  [1][2]
 
Reference:
[1] J Med. Chem. 2007, 50, 3442-3456.
[2] Bioorg. Med. Chem. Lett. 2008, 18, 6562-6567.
 
 
Chemical Information
Molecular Weight (WM):
324.38
Formula:
C15H24N4O4
CAS No:
348622-88-8
Purity:
≥ 98%
Synonyms:
UK 383367
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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