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Product name : YM 155
Item : cc-42
Price : 10mg, $100; 25mg. $200; 100mg, $700; 200mg, $1050
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
YM 155 is the first-in-class surviving inhibitor with an IC50 0.54 nM, selectively inhibits survivin expression and induces apoptosis in tumor cells. YM 155 is in clinical trials. Survivin is a member of the inhibitor of apoptosis (IAP) gene family, and is expressed during embryonal development, but is absent in most normal, terminally differentiated tissues. Survivin is upregulated in a variety of human cancers. Expression of suvivin in tumors is associated with a more aggressive phenotype, shorter survivial times, and a decreased response to chemotherapy.[1][2][3]
 
 
Reference:
[1] Cancer Res. 2007, 67, 8014-8021.
[2] J Clin. Oncol. 2009, 27, 4481-4486.
[3] J Clin. Oncol. 2008, 26, 5198-5203.                                               
 
Chemical Information
Molecular Weight (WM):
443.29
Formula:
C20H19BrN4O3
CAS No:
781661-94-7
Purity:
≥ 98%
Synonyms:
N/A
 
DMSO ≥ 89mg/mL
Solubility: (R.T.: 25℃):
Water ≥ 89mg/mL
 
Ethanol ≥ 24 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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