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Product name : VU 0357121
Item : cc377
Price : 10mg, $90; 50mg, $395; 100mg, $595; 200mg,$895
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
VU-0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Its site of action is distinct from the classical mGlu5 negative allosteric modulator (NAM) MPEP allosteric site or the site of a recetly discovered PAM, CPPHA. However, VU 0357121 shares a functional interaction with the MPEP site. VU0357121 is highly selective for activation of mGlu5 and is inactive or very weakly antagonizing at other mGlu receptor subtypes. [1]
 
Reference:
[1] ACS Chem. Neruosci. 2010, 1, 702-716.
 
 
Chemical Information
Molecular Weight (WM):
305.32
Formula:
C17H17F2NO2
CAS No:
433967-28-3
Purity:
≥ 98%
Synonyms:
VU0357121
 
DMSO ≥ 61 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 21 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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