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Product name : Bardoxolone methyl
Item : cc371
Price : 10mg, $110; 50mg, $250; 100mg, $395; 200mg, $495
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2, an important biological target that controls the production of many of the body's antioxidant and detoxification enzymes. Because oxidative stress and inflammation occur throughout the course of chronic kidney disease (CKD) and are known to contribute to loss of kidney function, agents that activate the Nrf2 pathway in patients with CKD may provide a novel method for preserving or improving kidney function. Bardoxolone methyl(NSC-713200; RTA-402; CDDO Methyl ester) is currently being investigated as a potential oral once-a-day treatment for CKD.  [1][2]
                                                                              
Reference:
[1] Am. J Physiol. Renal Physiol. 2011, 300, F1180-1192.
[2] Am. J Nephrol. 2011, 33, 469-476.
 
 
Chemical Information
Molecular Weight (WM):
505.69
Formula:
C32H43NO4
CAS No:
218600-53-4
Purity:
≥ 98%
Synonyms:
NSC713200. RTA402
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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