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Product name : A 803467
Item : cc433
Price : 10mg, $60; 50mg, $245; 100mg, $450; 200mg; $795
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Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM. A 803467 potently blocks recombinant human or rat NaV1.8 channels with IC50 of 8 nM and 45 nM, respectively, at a holding potential of -40 mV. At a resting state, A803467 also potently blocks human NaV1.8 channels with IC50 of 79 nM. A-803467 blocks tetrodotoxin-resistant (TTX-R) currents in rat dorsal root ganglion neurons in a concentration-dependent manner with IC50 of 140 nM, more potently compared with both mexiletine and lamotrigine with IC50 of >30 μM. A-803467 displays 300- to 1,000-fold higher selectivity for hNaV1.8 over hNaV1.2, hNaV1.3, hNaV1.5, and hNaV1.7 channels with IC50 of 7.38 μM, 2.45 μM, 7.34 μM, and 6.74 μM, respectively. A-803467 shows no significant activity against other channels and receptors.   [1][2]
 
Reference:
[1] Proc. Natl. Acad. Sci. USA 2007, 104, 8520-8525.
[2] J Pain 2009, 10, 306-315.
 
 
Chemical Information
Molecular Weight (WM):
357.79
Formula:
C19H16ClNO4
CAS No:
944261-79-4
Purity:
≥ 98%
Synonyms:
A-803467
 
DMSO ≥ 72 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 11 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃       in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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