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Product name : PF 670462
Item : cc367
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 950912-80-8
Molecular Weight : 410.32
Formula : C₁₉H₂₂Cl₂FN₅
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PF 670462 acts as a potent and reversible inhibitor of casein kinase Iε/δ (IC50 = 7.7 and 14 nM, respectively) with modest to excellent selectivity over EGFR and p38 MAPK (IC50 = 150 and 190 nM, respectively) and over 43 related kinases (IC50 > 0.3 to 30 µM), and a panel containing 116-receptors, transporters and other enzymes. PF670462 inhibits PER3 nuclear translocation in GFP-PER3 and CKIε-cotransfected COS7 cells (EC50 = 290 nM), and induces phase delays in circadian rhythms of monkeys & rats model (10 - 100 mg, s.c.); further, attenuate the locomotor stimulant response to methamphetamine.   [1]
 
Reference:
[1] J Pharmacol. Exp. Ther. 2007, 322, 730-738.
 
 
Chemical Information
Molecular Weight (WM):
410.32
Formula:
C19H20FN5·2HCl
CAS No:
950912-80-8  
Purity:
≥ 98%
Synonyms:
PF-670462
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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