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Products > Receptor Tyrosine Kinase > EGFR > Erlotinib (CP 358774, OSI 774, NSC 718781)
Product name : Erlotinib (CP 358774, OSI 774, NSC 718781)
Item : cc556
Price : 5g, $650;10g, $1050; 20g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 183319-69-9
Molecular Weight : 429.9
Formula : C₂₂H₂₄ClN₃O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Erlotinib Hydrochloride (CP-358774, OSI-774, NSC-718781, Tarceva) is a HER1/EGFR inhibitor with IC50 of 2 nM. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation.   [1][2]
 
Reference:
[1] J Pharmacol. Exp. Ther. 1999, 291, 739-748.
[2] Clin. Cancer Res. 2001, 7, 2958-2970.
 
 
Chemical Information
Molecular Weight (WM):
429.90
Formula:
C22H23N3O4·HCl
CAS No:
183319-69-9, 183321-74-6 (free base), 248594-19-6 (methanesulfonate)
Purity:
≥ 98%
Synonyms:
Tarceva, OSI774, CP358774, NSC718781
 
DMSO ≥ 3 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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