Apoptosis
KSp
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Product name : CCT 137690
Item : cc66
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1095382-05-0
Molecular Weight : 551.48
Formula : C₂₆H₃₁BrN₈O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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CCT137690 is a highly selective Aurora kinases inhibitor to Aurora-A, Aurora-B and Aurora-C with IC50 of 15 nM, 25 nM and 19 nM, respectively. CCT-137690 exhibits anti-proliferative activity against a wide range of human solid tumour cell lines. CCT137690 efficiently inhibits histone H3 and TACC3 phosphorylation (Aurora B and Aurora A substrates, respectively) in HCT116 and HeLa cells. Continuous exposure of tumour cells to the inhibitor causes multipolar spindle formation, chromosome misalignment, polyploidy and apoptosis. [1][2]
Reference:
[1] J Med. Chem. 2010, 53, 5213-5228.
[2] Mol. Cancer Ther. 2011, 10, 2115-2123.
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Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
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