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Product name : Rucaparib (AG 014699, PF 01367338)
Item : cc55
Price : 10mg, $140; 50mg,$595; 100mg, $895; 200mg,$1895
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM.Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks. [1][2]
 
Reference:
[1] Oncogene 2012, 31, 251-264.
[2] Mol. Cancer Ther. 2007, 6, 845-956.
 
 
Chemical Information
Molecular Weight (WM):
421.36
Formula:
C19H18FN3O·H3PO4
CAS No:
459868-92-9
Purity:
≥ 98%
Synonyms:
AG014699, PF01367338,
 
DMSO ≥ 84 mg/mL
Solubility (25℃)
Water ≥ 60 mg/mL
 
Ethanol ≥ 7 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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