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Product name : ZM 336372
Item : cc52
Price : 10mg, $95, 50mg, $295; 100mg, $545; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM. ZM 336372 inhibits c-Raf by competing with ATP to bind to the protein. Alternate studies suggest that ZM 336372 can induce apoptosis in pancreatic adenocarcinoma cell lines by inhibiting glycogen synthase kinase-3β, GSK-3β through phosphorylation of GSK-3&beta at Ser 9. In addition, ZM-336372 can suppress the proliferation of hepatocellular carcinoma cells by inhibiting hormone secretion and up-regulating cell cycle inhibitors. Furthermore, ZM336372 can also act as an agonist towards c-Raf, activating the MAPK pathway, which can be suppressed after activation by c-Raf itself, using a novel feedback loop in which activation is always followed by inactivation. [1][2]
 
Reference:
[1] Chem. Biol. 1999, 6, 559-568.
[2] Mol. Cancer Res. 2005, 4, 910-917.
 
 
Chemical Information
Molecular Weight (WM):
389.450
Formula:
C23H23N3O3
CAS No:
208260-29-1
Purity:
≥ 98%
Synonyms:
ZM 336372
 
DMSO ≥ 78 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 6 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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