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Product name : BIX 02189
Item : cc46
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1265916-41-3
Molecular Weight : 440.54
Formula : C₂₇H₂₈N₄O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively. Pretreatment with BIX02189 inhibits sorbitol-induced phosphorylation of ERK5 in HeLa cells in a dose dependent manner, and displays no inhibitory activity against the phosphorylation of ERK1/2, p38, and JNK1/2 MAPKs.  [1][2]
 
Reference:
[1] Biochem. Biophys. Res. Commun. 2008, 377, 120-125.
[2] Circ. Res. 2010, 106, 961-970.
 
 
Chemical Information
Molecular Weight (WM):
440.54
Formula:
C27H28N4O2
CAS No:
1094614-85-3
Purity:
≥ 98%
Synonyms:
BIX-02189
 
DMSO ≥ 88 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 88 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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