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Products > MAPK > Raf > PLX 4032 (RG 7204, Zelboraf, RO 5185426)
Product name : PLX 4032 (RG 7204, Zelboraf, RO 5185426)
Item : cc7
Price : 1g, $650;2g, $1050; 5g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 918504-65-1
Molecular Weight : 489.92
Formula : C₂₃H₁₈ClF₂N₃O₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RAFV600E with IC50 of 31 nM. PLX-4032 selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation. Approximately 90% of BRAF gene mutations involve a valine-to-glutamic acid mutation at residue 600 (V600E); the oncogene protein product, BRAF(V600E) kinase, exhibits a markedly elevated activity that over-activates the MAPK signaling pathway. The BRAF(V600E) gene mutation has been found to occur in approximately 60% of melanomas, and in about 8% of all solid tumors, including melanoma, colorectal, thyroid and other cancers.  [1][2]
 
Reference:
[1] Nature 2010,467, 596-599.
[2] Cancer Res. 2010, 70, 5518-5527.
 
 
Chemical Information
Molecular Weight (WM):
489.92
Formula:
C23H18ClF2N3O3S
CAS No:
918504-65-1, 918505-61-0, 1029872-54-5
Purity:
≥ 98%
Synonyms:
RG-7204, RO-5185426
 
DMSO ≥ 98 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol <1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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