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Product name : CX 5461
Item : cc1
Price : 10mg, $265; 50mg, $795; 100mg, $1395; 200mg, $2295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 μM. Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation. RNA Polymerase I (Pol I), the multi-protein complex that synthesizes rRNA, is activated widely in cancer. Thus, selective inhibitors of RNA PolI may offer a general therapeutic strategy to block cancer cell proliferation. CX5461 selectively blocks RNA PolI transcription,PIC assembly and SL1-rDNA interaction. CX 5461 indicates potent antiproliferative activity in cancer cells and induces autophagy incancer cells. CX-5461 shows potent antitumor activity in A375 and MiaPaca xenografts.  [1][2]
 
Reference:
[1] Cancer Cell 2012, 22, 51-65.
[2] Cancer Res. 2011, 71, 1418-1430.
 
 
Chemical Information
Molecular Weight (WM):
513.61
Formula:
C27H27N7O2S
CAS No:
1138549-36-6
Purity:
≥ 98%
Synonyms:
 
 
DMSO < 1 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol <1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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