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Product name : AZD 7762
Item : cc363
Price : 10mg, $175; 50mg, $595; 100mg, $945; 200mg, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
AZD7762 is a novel, checkpoint kinase inhibitor with IC50 values of 5 and <10 nM for CHK1 and CHK2, respectively.  AZD-7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. This agent may enhance the cytotoxicity of DNA-damaging agents. Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication, Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication.   [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2008, 7, 2955-2966.
[2] Int. J Cancer 2011, 129, 1953-1962.
 
 
Chemical Information
Molecular Weight (WM):
362.42
Formula:
C17H19FN4O2S
CAS No:
860352-01-8, 1246094-78-9 (HCl), 1192875-06-1 (Fumaric acid)
Purity:
≥ 98%
Synonyms:
AZD7762
 
DMSO ≥ 73 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 3 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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