Apoptosis
Aurora Kinase
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Product name : AZD 7762
Item : cc363
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 860352-01-8
Molecular Weight : 362.42
Formula : C₁₇H₁₉FN₄O₂S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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AZD7762 is a novel, checkpoint kinase inhibitor with IC50 values of 5 and <10 nM for CHK1 and CHK2, respectively. AZD-7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. This agent may enhance the cytotoxicity of DNA-damaging agents. Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication, Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication. [1][2]
Reference:
[1] Mol. Cancer Ther. 2008, 7, 2955-2966.
[2] Int. J Cancer 2011, 129, 1953-1962.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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