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Product name : A 769662
Item : cc24
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 844499-71-4
Molecular Weight : 360.39
Formula : C₂₀H₁₂N₂O₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
A-769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 μM) that displays selectivity towards β1 subunit-containing heterotrimers. A-769662 inhibits fatty acid synthesis (IC50 = 3.2 μM) and decreases plasma glucose and triglyceride levels in vivo. A769662 inhibits proteasomal function by an AMPK-independent mechanism. A 769662 affects the in vitro activity of purified 26S proteasomes but not the in vitro activity of purified 20S proteasomes. A-769662 has toxic effects on MEF cells. [1][2]
 
Reference:
[1] J Biol. Chem. 2007, 282, 32539-32548.
[2] FEBS Lett. 2008, 583, 2650-2654.
 
 
Chemical Information
Molecular Weight (WM):
360.39
Formula:
C20H12N2O3S
CAS No:
844499-71-4
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 72 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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