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Products > Receptor Tyrosine Kinase > VEGFR > Vandetanib (Zactima, ZD 6474)
Product name : Vandetanib (Zactima, ZD 6474)
Item : cc112
Price : 10mg, $45; 50mg, $145; 100mg, $225; 200mg, $455
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Vandetanib (Zactima, ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.  [1][2]
 
Reference:
[1] Cancer Res. 2002, 62, 4645-4655.
[2] Clin. Cancer Res. 2003, 9, 1546-1556.
 
 
Chemical Information
Molecular Weight (WM):
475.354
Formula:
C22H24BrFN4O2
CAS No:
443913-73-3
Purity:
≥ 98%
Synonyms:
ZD 6474, ZD-6474
 
DMSO ≥ 4 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥  mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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