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Products > Receptor Tyrosine Kinase > VEGFR > Axitinib (AG 013736)
Product name : Axitinib (AG 013736)
Item : cc356
Price : 50mg, $55; 100mg, $95; 200mg, $220, 1g, $745
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Axitinib (AG-013736) is a multiple receptor kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-β and c-KIT with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor (PDGF), thereby exerting an anti-angiogenic effect.  [1][2]
 
Reference:
[1] Clin. Cancer Res. 2008, 14, 7272-7283.
[2] Int. J Cancer 2011, 128, 2748-2758.
 
 
Chemical Information
Molecular Weight (WM):
386.47
Formula:
C22H18N4OS
CAS No:
319460-85-0
Purity:
≥ 98%
Synonyms:
AG013736
 
DMSO < 1 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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