Favorite  |  Set Home
Products > Others > > Ezetimib
Product name : Ezetimib
Item : cc336
Price : 10mg, $25; 50mg, $75; 100mg, $95; 200mg, $175
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
Ezetimibe (Zetia) localises at the brush border of the small intestine, where it inhibits the absorption of cholesterol from the intestine. Specifically, it appears to bind to a critical mediator of cholesterol absorption, the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells as well as in hepatocytes. In addition to this direct effect, decreased cholesterol absorption leads to an upregulation of LDL-receptors on the surface of cells and an increased LDL-cholesterol uptake into cells, thus decreasing levels of LDL in the blood plasma which contribute to atherosclerosis and cardiovascular events. [1][2]
 
Reference:
[1]JAMA 2008, 299, 2266.
[2] Proc. Natl. Acad. Sci. USA 2005, 102, 8132-8137.
 
 
Chemical Information
Molecular Weight (WM):
409.43
Formula:
C24H21FNO3
CAS No:
104632-25-9
Purity:
≥ 98%
Synonyms:
Zetia
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
LRRK2-IN-1
LRRK2-IN-1
ASC-J9 (GO-Y025, Dimethylcurcumin)
ASC-J9 (GO-Y025, Dimethylcurcumin)
Price: 10mg, $175; 50mg, $595; 100mg, $945; 200mg, $1795
PF 04971729
PF 04971729
Price: 10mg, $295; 50mg, $795; 100mg, $1295; 200mg, $1995
GW 2580
GW 2580
Price: 50mg, $195; 100mg, $395; 200mg, $695, 1g, $1295
Mozavaptan
Mozavaptan
Price: 10mg, $125; 50mg, $395; 100mg, $595; 200mg, $995
Cidofovir
Cidofovir
Price: 50mg, $65; 100mg, $95; 200mg, $245, 1g, $645
Retapamulin (SB 275833)
Retapamulin (SB 275833)
Price: 10mg, $125; 50mg, $495; 100mg, $995; 200mg, $1695
LY 2886721
LY 2886721
Price: 10mg, $275; 50mg, $845; 100mg, $1295; 200mg, $2295