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Product name : Ramelteon (TAK 375, Rozerem)
Item : cc321
Price : 1g, $650;2g, $1050; 5g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 196597-26-9
Molecular Weight : 259.34
Formula : C₁₆H₂₁NO₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Ramelteon (TAK-375, Rozerem) showed very high affinity for human MT1 (Mel1a) and MT2 (Mel1b) receptors and chick forebrain melatonin receptors with Ki values of 14.0, 112, and 23.1 pM, respectively, making the affinities of ramelteon for these receptors 3-16 times higher than those of melatonin. Ramelteon inhibited forskolin-stimulated cAMP production in the CHO cells that express the human MT1 or MT2 receptors. Taken together, these results indicate that ramelteon is a potent and highly selective agonist of MT1/MT2 melatonin receptors. [1][2]
 
Reference:
[1] Neurophamacology 2005, 48, 301-310.
[2] Sleep 2004, 27, 1319-1325.
 
 
Chemical Information
Molecular Weight (WM):
259.34
Formula:
C16H21NO2
CAS No:
196597-26-9
Purity:
≥ 98%
Synonyms:
TAK375
 
DMSO ≥ 52 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 52 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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