Zosuquidar trihydrochloride/RS 33295-198/RS-33295-198/LY335979/LY-335979/LY 335979/167465-36-3/167354-41-8/acesobio supply

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Products > Transmembrane Transporter > P-gp > LY 335979 (Zosuquidar trihydrochloride, RS 33295-198)

Product name : LY 335979 (Zosuquidar trihydrochloride, RS 33295-198)

Item : cc68

Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590

contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.

CAS : 167465-36-3

Molecular Weight : 636.99

Formula : C₃₂H₃₄Cl₃F₂N₃O₂

Storage : at -20°C

Additional information : We offer significant discount for bulky quantity order

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Details:

LY335979 (Zosuquidar trihydrochloride, RS 33295-198) binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents.^[1][2]

Reference:

[1] Cancer Res. 1996, 56, 4171-4179.

[2] J Pharmacol. Exp. Ther. 2011, 337, 710-717.

Chemical Information

Molecular Weight (WM):	636.99
Formula:	C₃₂H₃₂F₂N₃O₂·3HCl
CAS No:	167465-36-3, 167354-41-8 (free base)
Purity:	≥ 98%
Synonyms:	LY-335979, RS-33295-198
	DMSO ≥ 127 mg/mL
Solubility (25℃)	Water ≥ 23 mg/mL
	Ethanol < 1 mg/mL
	2 years -20℃ Powder
Stability:	2 weeks -4℃ in DMSO
	2 months -80℃ in DMSO

Quality control data:

Quality control by ¹H-NMR, ¹³C-NMR, HPLC and LCMS.

Product will be shipped with supporting analytical data.

PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.

NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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