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Product name : AST 6
Item : cc284
Price : 10mg, $195; 50mg, $795; 100mg,$1295; 200mg, $2155
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
AST-6, a rationally designed novelanilinoquinazoline compound, inhibited enzymatic activitiesof wild type EGFR and ErbB2 as well as EGFR L858R/T790M resistantmutant both in cell-free and cell-based levels. Importantly, AST6 functions as an irreversible inhibitor, most likely bycovalent modification of Cys 797 and Cys 805 in the catalyticdomains of EGFR and ErbB2, respectively. Further studies showedthat AST 6 inactivated their downstream pathways and therebyinhibited the proliferation of a panel of cancer cell lines. [1]
 
Reference:
[1] Mol. Cancer Ther. 2009, 8, Supplement 1.
 
 
Chemical Information
Molecular Weight (WM):
621.08
Formula:
C31H26ClFN4O5S
CAS No:
1050500-29-2
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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