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Product name : SB 705498
Item : cc315
Price : 10mg, $195; 50mg, $795; 100mg,$1295; 200mg, $2155
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
SB705498 is a TRPV1 antagonist for hTRPV1 with pIC50 and pKi of 7.1 and 7.6 in HEK293 cells.  Vanilloid receptor-1 (TRPV1) is a nonselective cation channel, predominantly expressed by sensory neurons, which plays a key role in the detection of noxious painful stimuli such as capsaicin, acid, and heat. TRPV1 antagonists may represent novel therapeutic agents for the treatment of a range of conditions including chronic pain, migraine, and gastrointestinal disorders. [1][2]
 
Reference:
[1] J Pharmacol. Exp. Ther. 2007, 321, 1183-1192.
[2] Bioorg. Med. Chem. Lett. 2006, 16, 3287-3291.
 
 
Chemical Information
Molecular Weight (WM):
429.23
Formula:
C17H16BrFN4O
CAS No:
501951-42-4
Purity:
≥ 98%
Synonyms:
SB-705498
 
DMSO ≥ 86 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 20 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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