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Product name : ABT-737
Item : cc-242
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 852808-04-9
Molecular Weight : 813.43
Formula : C₄₂H₄₅ClN₆O₅S₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
ABT-737 is a cell-permeant pan-Bcl-2 inhibit that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts. Increased expression of the Bcl-2 family of protein in cancers has been associated with chemotherapy resistance. Inhibiting Bcl-2 or Bcl-XL overexpression could potentially induce apoptosis in cancer cells while having minimal effects on normal cells. The ABT-737 single-agent LC90 values ranged from 100 nM for COG-LL-319 and RS4 11cells to low micromolar concentrations for the other five ALL cell lines. [1][2]
 
Reference:
[1] Cancer Res. 1994, 54, 6-8.
[2] Clin.Cancer Res. 2007, 13, 621-629.
                                           
Chemical Information
Molecular Weight (WM):
813.4
Formula:
C42H45ClN6O5S2
CAS No:
852808-04-9
Purity:
≥ 98%
Synonyms:
ABT 737
 
DMSO ≥ 163 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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