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Product name : PF 431396
Item : cc292
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 717906-29-1
Molecular Weight : 506.5
Formula : C₂₂H₂₁F₃N₆O₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively).  Proline-rich tyrosine kinase 2 (PYK2) is a cytoplasmic, non-receptor tyrosine kinase implicated in multiple signaling pathways. It is a negative regulator of osteogenesis and considered a viable drug target for osteoporosis treatment. PF431396 promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. PF 431396 is used in treatment of osteoporosis. [1][2]
 
Reference:
[1] J Biol Chem. 2009, 284, 13193-13201.
[2] J Biol Chem. 2009, 284, 22865-22877.
 
 
Chemical Information
Molecular Weight (WM):
506.50
Formula:
C22H21F3N6O3S
CAS No:
717906-29-1
Purity:
≥ 98%
Synonyms:
PF 431396
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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