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Product name : PF 562271
Item : cc23
Price : 10mg, $195; 50mg, $795; 100mg,$1295; 200mg, $2155
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
PF-562271 is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and Pyk2 catalytic activity with IC50 of 1.5 nM and 14 nM, respectively.  And in cell-based assays, the IC50 of PF562271 is shown to be 5 nM for FAK, which is more selective compared to other kinase targets. In 2 dimensional (2D) cultures, PF-562271 results in a dose-dependent cell proliferation inhibition in FAK WT, FAK−/− and FAK kinase-deficient (KD) cells with IC50 of 3.3 μM, 2.08 μM and 2.01 μM, respectively. [1][2]
 
Reference:
[1] Cancer Res. 2008, 68, 1935-1944.
[2] Cancer Biol. Ther. 2010, 10, 38-43.
 
 
Chemical Information
Molecular Weight (WM):
665.66
Formula:
C21H20F3N7O3S.C6H6O3S
CAS No:
717907-75-0, 939791-38-5
Purity:
≥ 98%
Synonyms:
PF 562271
 
DMSO ≥ 5 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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