Apoptosis
Btk
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Product name : PF 573228
Item : cc288
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 869288-64-2
Molecular Weight : 491.49
Formula : C₂₂H₂₀F₃N₅O₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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PF-573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM). In whole-cell experiments, PF573228 reversibly increased the amplitude of Ca(2+)-activated K(+) currents (I(K(Ca))) in GH(3) cells. In inside-out recordings, this compound added to the bath did not modify single-channel conductance but stimulated large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels with an EC(50) value of 3.2 μM. [1][2]
Reference:
[1] Life Sci. 2011, 89, 691-701.
[2] Breast Cancer Res. Treat 2011, 125, 659-669.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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