Favorite  |  Set Home
Products > Protease > Proteasome > Delanzomib (CEP 18770)
Product name : Delanzomib (CEP 18770)
Item : cc287
Price : 10mg, $295; 50mg, $795; 100mg, $1395; 200mg, $2395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
 Enlarge Image                   Back
←[Previous Product]             


Details:
Delanzomib (CEP-18770) is a potent chymotrypsin-like proteasome inhibitor with an IC50 of 3.8 nM.Delanzomib (CEP18770) represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB. [1][2]
 
Reference:
[1] Blood 2008, 111, 2765-2775.
[2] Br. J Haematol. 2010, 148, 569-581.
 
 
Chemical Information
Molecular Weight (WM):
413.28
Formula:
C21H28BN3O5
CAS No:
847499-27-8
Purity:
≥ 98%
Synonyms:
CEP 18770
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
Carfilzomib (PR 171)
Carfilzomib (PR 171)
Price: 10mg, $275; 50mg, $695; 100mg, $1295; 200mg, $1995
BMS232632 (Atazanavir, Reyataz)
BMS232632 (Atazanavir, Reyataz)
Price: 10mg, $125; 50mg, $395; 100mg, $595; 200mg, $995
Oprozomib (ONX 0912)
Oprozomib (ONX 0912)
Price: 10mg, $375; 50mg, $895; 100mg, $1295;200mg, $1995
Indinavir
Indinavir
Price: 10mg, $95, 50mg, $395; 100mg, $675; 200mg, $995
ONX 0914 (PR 957)
ONX 0914 (PR 957)
Price: 10mg, $475; 50mg, $1795; 100mg, $2795;200mg, $3795
MLN-9708 (Ixazomib)
MLN-9708 (Ixazomib)
Price: 10mg, $225; 50mg, $795; 100mg, $1295; 200mg, $2195
Bortezomib (PS 341, MG 341)
Bortezomib (PS 341, MG 341)
Price: 10mg, $95, 50mg, $495, 100mg, $795; 200mg, $1175
MLN 2238
MLN 2238
Price: 10mg, $275; 50mg, $765; 100mg, $1295; 200mg, $2095