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Product name : LDE 225 (Erismodegib)
Item : cc76
Price : 10mg, $195; 50mg, $595; 100mg, $895; 200mg, $1455
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
LDE225 (NVP-LDE225, Erismodegib) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. Smo antagonist NVP-LDE225 inhibits Hh signaling and induces tumor regression in animal models of medulloblastoma. LDE-225 significantly reduced tumor volume by 95% compared with untreated control mice. Hedgehog inhibition with LDE225 significantly prolonged median survival in the used transgenic mouse model.  [1][2]
 
Reference:
[1] Sci. Transl. Med. 2010, 2, 51a70.
[2] Ann. Surg. 2011, 254, 818-823.
 
 
Chemical Information
Molecular Weight (WM):
485.50
Formula:
C26H26F3N3O3
CAS No:
956697-53-3, 1270169-93-1, 1218778-76-7 (HCl)
Purity:
≥ 98%
Synonyms:
LDE 225
 
DMSO ≥ 97 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 97 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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