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Product name : Navitoclax (ABT 263)
Item : cc-344
Price : 200mg, $550;500mg, $950; 1g $1650; 2g, $2850
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 923564-51-6
Molecular Weight : 974.61
Formula : C₄₇H₅₅ClF₃N₅O₆S₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
Navitoclax (ABT-263) is a novel small molecule dual Bcl-2/Bcl-xL inhibitor designed to restore apoptosis, also known as programmed cell death, by blocking the function of pro-survival Bcl-2 family proteins. Binding affinities were determined with competitive fluorescence polarization assays (Ki’s of < 1 nmol/L for Bcl-2, Bcl/xL, and Bcl-W). The Bcl-2 family proteins, which are expressed at high levels in many tumors, play a central role in regulating apoptosis and, consequently, are thought to impact tumor formation, tumor growth and resistance.[1][2]
 
Reference:
[1] Cancer Res. 2008, 68, 3421-3428.
[2] Clin. Cancer Res. 2008, 14, 3268-3277.
 
                                          
Chemical Information
Molecular Weight (WM):
974.61
Formula:
C47H55ClF3N5O6S3
CAS No:
923564-51-6
Purity:
≥ 98%
Synonyms:
ABT-263
 
DMSO ≥ 195 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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