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Product name : BMS 599626 (AC 480)
Item : cc199
Price : 10mg, $295; 50mg, $795; 100mg, $1395; 200mg, $2395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
BMS-599626 (AC-480) is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50=22, 32 and 190 nM, respectively) with potential antineoplastic activity. Pan-HER kinase inhibitor BMS599626(AC480) binds to and inhibits the human epidermal growth factor receptors (HER) HER1 (EGFR), HER2 (ErbB-2) and HER4, which may prevent downstream signaling and inhibit the proliferation of tumor cells that overexpress these receptors. In addition, this agent may enhance the radiosensitivity of certain tumor cell types that express HER1 and HER2 through cell cycle redistribution in G1 phase and inhibition of DNA repair. EGFRs, frequently overexpressed on tumor cells, play a key role in tumor cell proliferation and survival. [1][2]
 
Reference:
[1] Mult. Scler. 2000, 99-104.
[2] Lancet 2008, 371, 2085-2092.
 
 
Chemical Information
Molecular Weight (WM):
567.01
Formula:
C27H27FN8O3·HCl
CAS No:
714971-09-2, 873837-23-1 (HCl), 873837-22-0 (H2O)
Purity:
≥ 98%
Synonyms:
BMS 599626, AC 480
 
DMSO ≥ 113 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 20 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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