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Product name : MEK 162
Item : cc-455
Price : 10mg, $195; 50mg, $495; 200mg, $1395
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
MEK 162 (ARRY-162) is an orally available inhibitor of MEK1 and MEK2 with potential antineoplastic activity. MEK 162, noncompetitive with ATP, binds to and inhibits the activity of MEK1 and MEK2. Inhibition of MEK1/2 prevents the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling. This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines. MEK 162 is now being investigated in Phase I trials in advanced solid tumors. [1][2]
 
Reference:
[1] WO 2010083975 A1 20100729.
[2] EP 2210615 A1 20100728.
 
                                          
Chemical Information
Molecular Weight (WM):
441.23
Formula:
C17H15BrF2N4O3
CAS No:
606143-89-9
Purity:
≥ 98%
Synonyms:
ARRY 162
 
DMSO N/A
Solubility: (R.T.: 25℃):
Water N/A
 
Ethanol N/A
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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