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Product name : Clofarabine
Item : cc157
Price : 10mg, $45; 50mg, $145; 100mg, $295; 200mg, $475
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase with IC50 of 65 nM and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis.  [1][2]
 
Reference:
[1] Clin. Caner Res. 2004, 9, 6335-6342.
[2] Blood 2004, 103, 784-789.
 
 
Chemical Information
Molecular Weight (WM):
303.68
Formula:
C10H11ClFN5O3
CAS No:
123318-82-1
Purity:
≥ 98%
Synonyms:
Clolar, Evoltra
 
DMSO ≥ 61 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 4 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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