Apoptosis
DHFR
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Product name : Clofarabine
Item : cc157
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 123318-82-1
Molecular Weight : 303.68
Formula : C₁₀H₁₁ClFN₅O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase with IC50 of 65 nM and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis. [1][2]
Reference:
[1] Clin. Caner Res. 2004, 9, 6335-6342.
[2] Blood 2004, 103, 784-789.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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